Menatetrenone
Menatetrenone.PNG
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code
  • none
Identifiers
Synonyms 3-methyl-2-[(2Z,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione
CAS Number
PubChem CID
UNII
KEGG
Chemical and physical data
Formula C31H40O2
Molar mass 444.648 g/mol
  (verify)

Menatetrenone (INN), also known as MK4, is a menaquinone compound used as a hemostatic agent and as adjunctive therapy for the pain of osteoporosis. It is marketed for the latter indication in Japan by Eisai Co., under the trade name Glakay.

Menatetrenone (MK4) is one of the nine forms of vitamin K2.[1]

MK4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls.[2] While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK4, studies demonstrate the conversion is not dependent on gut bacteria, occurring in germ-free rats[3][4] and in parenterally-administered K1 in rats.[5][6] In fact, tissues that accumulate high amounts of MK4 have a remarkable capacity to convert up to 90% of the available K1 into MK4.[7][8]

See also[edit]

References[edit]

  1. ^ Iwamoto J, Takeda T, Sato Y (2006). "Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis". Nutr. Rev. 64 (12): 509–17. PMID 17274493. doi:10.1111/j.1753-4887.2006.tb00184.x.  Unknown parameter |month= ignored (help)
  2. ^ Shearer, Shearer MJ (2008). "Metabolism and cell biology of vitamin K". Thrombosis and Haemostasis: 530–547. doi:10.1160/TH08-03-0147.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ Davidson, RT (1998). "Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1". Journal of Nutrition. 128 (2): 220–223. PMID 9446847.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  4. ^ Ronden, JE (1998). "Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat". Biochimica et Biophysica Acta (BBA) - General Subjects. 1379 (1): 69–75. PMID 9468334. doi:10.1016/S0304-4165(97)00089-5.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  5. ^ Thijssen, HHW (1994). "Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4". British Journal of Nutrition. 72 (3): 415–425. PMID 7947656. doi:10.1079/BJN19940043.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  6. ^ Will, BH (1992). "Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats". Journal of Nutrition. 122 (12): 2354–2360. PMID 1453219.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  7. ^ Davidson, RT (1998). "Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria". Journal of Nutrition. 128 (2): 220–223. PMID 9446847.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  8. ^ Ronden, JE (1998). "Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat". Biochimica et Biophysica Acta (BBA) - General Subjects. 1379 (1): 69–75. PMID 9468334. doi:10.1016/S0304-4165(97)00089-5.  Unknown parameter |coauthors= ignored (|author= suggested) (help)

External links[edit]